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        <title>Multi Scale Modeling of Chromatin and Nucleosomes</title>
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        <description>Strategic Programs for Innovative Research Field 1 Supercomputational Life Science http://www.scls.riken.jp/en/ Double-stranded DNA in which genetic information is encoded is folded into compact protein-DNA complex structures, called “chromatin", in a nucleus of cell. When DNA is transcribed into RNA for gene expression, chromatin has to be in relaxed conformations. These conformational changes are regulated by chemical modifications of histones and so on.  To study the complicated mechanism of life, three-dimensional structures of nucleosomes that compose the chromatin were constructed virtually and molecular dynamics (MD) simulations based on physical laws such as the equation of motion were conducted using the K computer. Such MD calculations enable us to simulate and observe dynamic behaviors of chromatin structures precisely. Simulations of biomolecules in cellular environments Graduate School of Medical Life Science, Yokohama City University Mitsunori Ikeguchi Quantum Beam Science Center Japan Atomic Energy Agency Hidetoshi Kono, Hisashi Ishida, Kimiyoshi Ikeda, Shun Sakuraba Graduate School of Science, Kyoto University Shojo Takada, Tsuyoshi Terakawa, Yusuke Takagi, Le Chang Art Direction Transistor Studio Music Yui Morishita Production Management Cybernet Systems Co.,Ltd. 3DCG Animation Design and Creation SCIEMENT, Inc. If you wish to use this material, please see: http://www.scls.riken.jp/en/information/movie-gallery.html</description>
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